Nimbus Health
Refer a patientSchedule a visit
Conditions/COPD
Chronic obstructive pulmonary disease

COPD.

U.S. prevalence
16M U.S. adults
True number is likely 24M. Fourth leading cause of death in the U.S.

COPD describes a group of progressive lung diseases — primarily emphysema and chronic bronchitis — that obstruct airflow and make breathing difficult. The damage is permanent and cumulative.

By the time most patients are diagnosed, they have lost 30–50% of their lung function. The most common cause by a wide margin is cigarette smoking, but COPD also occurs in non-smokers from long-term exposure to indoor cooking smoke, occupational dust, or rare genetic conditions (alpha-1 antitrypsin deficiency).

The graph to understand

The Fletcher–Peto curve — FEV1 decline by smoking status.

Smokers susceptible to COPD lose lung function 2–4 times faster than non-smokers — and the decline curve returns to the normal aging slope as soon as the patient stops smoking, at any age. A 60-year-old who quits has 20+ years of FEV1 decline that looks like a healthy non-smoker's.

0%25%50%75%100%253545556575FEV1 % predictedAgeDisability thresholdDeath thresholdquit at 45Never smokerSusceptible smokerQuit at 45
Quit age45
Reference
01What it is
02How it shows up
03How we diagnose it
04How we treat it
05What you can do

What it is

COPD describes a group of progressive lung diseases — primarily emphysema and chronic bronchitis — that obstruct airflow and make breathing difficult. The damage is permanent and cumulative. By the time most patients are diagnosed, they have lost 30–50% of their lung function. Roughly 16 million Americans have diagnosed COPD; the true number is higher, perhaps 24 million, because the disease often progresses for years before patients are tested. COPD is the fourth leading cause of death in the United States.

How it shows up

Early COPD often goes unrecognized. Patients attribute breathlessness to aging or being out of shape. By the time symptoms are obvious — daily cough with sputum, shortness of breath climbing a single flight of stairs, frequent winter infections — the disease is moderate-to-severe. A useful prompt: if you cannot walk and talk at the same time without becoming breathless, that is not normal at any age.

How we diagnose it

The diagnosis requires spirometry. We measure how much air you can blow out in one second (FEV1) after a bronchodilator. If your FEV1 divided by your total exhaled volume (FVC) is less than 0.70, you have airflow obstruction. We then stage severity (GOLD 1 through 4) based on the FEV1 percent predicted for your age, sex, and height. We also assess symptoms (mMRC or CAT score) and exacerbation history. The 2024 GOLD Report combines these into four groups (A, B, E) that guide treatment.

How we treat it

Smoking cessation is the single most important intervention, full stop. Nothing else slows decline as effectively. Inhaled bronchodilators (LAMA and LABA) are the foundation of maintenance therapy. Inhaled corticosteroids are added for patients with frequent exacerbations, especially with eosinophilic features. Pulmonary rehabilitation improves quality of life more than any single drug — yet less than 5% of eligible patients receive it. Vaccines (flu, pneumococcal, RSV, COVID) reduce exacerbations meaningfully. Oxygen for severe hypoxia improves survival. Lung volume reduction (surgical or via endobronchial valves) helps selected patients with severe emphysema.

What you can do

  • Stop smoking. Today. Use nicotine replacement, varenicline, bupropion — anything that works.
  • Get pulmonary rehabilitation if your provider recommends it. It changes lives.
  • Walk every day, even when you don't feel like it.
  • Take your inhalers daily, and get your inhaler technique checked.
  • Get every recommended vaccine.
References
  1. 01
    Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br Med J. 1977;1(6077):1645–1648.
    PMID: 871704
  2. 02
    Anthonisen NR, Connett JE, Kiley JP, et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1 (Lung Health Study). JAMA. 1994;272(19):1497–1505.
    PMID: 7966841
  3. 03
    Anthonisen NR, Skeans MA, Wise RA, et al. The effects of a smoking cessation intervention on 14.5-year mortality. Ann Intern Med. 2005;142(4):233–239.
    PMID: 15710956
  4. 04
    Scanlon PD, Connett JE, Waller LA, et al. Smoking cessation and lung function in mild-to-moderate chronic obstructive pulmonary disease. The Lung Health Study. Am J Respir Crit Care Med. 2000;161(2 Pt 1):381–390.
    PMID: 10673175

This page is general medical information, not personalized medical advice. If you have questions about your specific health, talk with your Nimbus clinician.

Care for copd

Find a clinician who treats COPD.

Eatonton · GA

Harold Jackson

Pulmonologist · MD, FCCP
Sun City West · AZ

Katherine Gross

Pulmonologist · MD
Easley · SC

Abbas Mansour

Pulmonologist · MD
Camelback · AZ

Ahmad El-Khatib

Pulmonologist · MD